Intramyocardial Delivery of Basic Fibroblast Growth Factor-Impregnated Gelatin Hydrogel Microspheres Enhances Collateral Circulation to Infarcted Canine Myocardium.
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چکیده
منابع مشابه
Intramyocardial delivery of basic fibroblast growth factor-impregnated gelatin hydrogel microspheres enhances collateral circulation to infarcted canine myocardium.
The present study examined whether basic fibroblast growth factor (bFGF)-impregnated acidic gelatin hydrogel microspheres (AGHM) would enhance collateral development to the infarct area in dogs with coronary occlusion. Studies were conducted in 28 dogs with a 2-week occlusion of the proximal left anterior descending coronary artery (LAD). The dogs were divided into 3 groups according to treatme...
متن کاملFactor for the Development of Functional Collateral Vessels Gelatin Hydrogel Microspheres Enable Pinpoint Delivery of Basic Fibroblast Growth
Akihiro Hosaka, Hiroyuki Koyama, Toshihiro Kushibiki, Yasuhiko Tabata, Nobuhiro Factor for the Development of Functional Collateral Vessels Gelatin Hydrogel Microspheres Enable Pinpoint Delivery of Basic Fibroblast Growth Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2004 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Green...
متن کاملGelatin hydrogel microspheres enable pinpoint delivery of basic fibroblast growth factor for the development of functional collateral vessels.
BACKGROUND Various growth factors promote collateral vessel development and are regarded as promising for the treatment of vascular occlusive diseases. However, an efficacious delivery system for them has yet to be established. We devised a strategy to augment functional collateral vessels by using acidic gelatin hydrogel microspheres (AGHMs) incorporating basic fibroblast growth factor (bFGF)....
متن کاملEffects of basic fibroblast growth factor microspheres on angiogenesis in ischemic myocardium and cardiac function: analysis with dobutamine cardiovascular magnetic resonance tagging.
OBJECTIVE Therapeutic angiogenesis with angiogenic growth factors has described as one of the promising methods for collateral formation in the treatment of ischemic heart diseases. The purpose of this study is to assess the value of intramyocardial injection of slow-released basic fibroblast growth factor microspheres on angiogenesis and cardiac function in the early period of acute infarcted ...
متن کاملEnhanced intestinal anastomotic healing with gelatin hydrogel incorporating basic fibroblast growth factor.
Anastomotic leakage is a common complication of intestinal surgery. In an attempt to resolve this issue, a promising approach is enhancement of anastomotic wound healing. A method for controlled release of basic fibroblast growth factor (bFGF) using a gelatin hydrogel was developed with the objective of investigating the effects of this technology on intestinal anastomotic healing. The small in...
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ژورنال
عنوان ژورنال: Japanese Circulation Journal
سال: 2001
ISSN: 0047-1828,1347-4839
DOI: 10.1253/jcj.65.439